All posts related to "RA"

Paralympian Leigh Walmsley: Bull’s eye on RA

Shadow of an archerBritish archer Leigh Walmsley competed at the London 2012 Paralympic game despite living with rheumatoid arthritis (RA). Her target is clear: continue to manage her RA while participating in competitive archery locally and nationally.

Walmsley experienced symptoms of RA in her 20s. She recalled feeling progressively worsening stiffness and soreness over weeks and months, especially in the morning and evening. She did not receive a diagnosis until she was 30. Even now, 24 years later, she continues to experience fatigue from RA and admits that her RA is not as controlled as she’d like it to be.  Continue reading

Call for patient input on SEB etanercept for RA and AS

Stickman with megaphone calling for patient input

Call for patient input on SEB etanercept for rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Do you have RA or AS or care for someone who does? We need your valuable input.

Health Canada defines subsequent entry biologics (SEBs) as biologic medicines that are similar to, and would enter the market after an approved innovator biologic (such as Enbrel®).

Unlike the more common small-molecule drugs, biologics generally exhibit high molecular complexity, and are sensitive to changes in manufacturing practices. SEBs are not identical to their innovator products because their chemical characteristics cannot be precisely duplicated during the manufacturing process. Therefore, SEBs may have unique efficacy, immunogenicity, and safety profiles that are different from their innovator products.

The Common Drug Review (CDR) is currently welcoming patients and their caregivers to provide input to patient organizations on the manufacturer’s submission for SEB etanercept for the treatment of rheumatoid arthritis or ankylosing spondylitis. The innovator biologic, or reference product, is etanercept (Enbrel®). Continue reading

Increased risk of chronic kidney disease in RA patients

A picture of a kidney in human hand

Image courtesy of Anusorn P nacho at FreeDigitalPhotos.net

According to a recent research study, rheumatoid arthritis (RA) patients are at an increased risk for chronic kidney disease (CKD). Along with CKD, researchers also observe increased inflammation within the first year of diagnosis, corticosteroid usage, hypertension, and obesity.

In the study, researchers monitored 813 Mayo Clinic patients with RA and 813 patients without RA for 20 years. They found that RA patients had a one in four chance of developing CKD, while the general public had a one in five chance. “That might not seem like a lot, but in fact that’s quite a big difference, and it has important implications for the course of rheumatoid arthritis and for the management of the disease,” said Dr. Eric Matteson, senior author of the study. Continue reading